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quinine

Scientific Name: Cinchona officinalis

Family: Rubiaceae

Category: Dicot

Growth:

Duration:

Other Names:

       

Quinine: An Overview

Quinine is a medication primarily known for its use in preventing and treating malaria, particularly malaria caused by Plasmodium falciparum. It is also used to treat babesiosis.

Considerations for Pets

  • Quinine is a bitter-tasting compound.

Common Uses and Applications

  • Malaria Treatment: Historically and presently, quinine is a key drug in combating malaria. It works by killing the parasites transmitted through mosquito bites.
  • Treatment for Babesiosis: Quinine is also employed in the treatment of babesiosis.
  • Fever Reducer and Painkiller: Traditionally, quinine has been used for its fever-reducing and painkilling properties.
  • Ingredient in Tonic Water: Quinine imparts the characteristic bitterness to tonic water.

Botanical Source

  • Quinine is derived from the bark of the cinchona tree. The brand name Fever-Tree refers to the colloquial name of the cinchona tree.
  • Cinchona, or quinine bark, is recognized as one of the rainforest's most famous and important discoveries.

Pharmacological Information

  • Quinine sulphate belongs to a group of medicines called anti-protozoal agents.
  • It can be administered in tablet form (200 mg, 300 mg base as sulfate) or as an injection (150 mg, 300 mg base as dihydrochloride per ml in 2-ml ampoule).
  • Quinine is classified as an antimalarial agent (P01B ANTIMALARIALS P01BC Methanolquinolines P01BC01 Quinine).

Historical Context

  • Quinine has been used for nearly 400 years as an effective anti-malarial drug.
  • The use of cinchona bark as a malaria treatment dates back to the 17th century.
  • During the Civil War, commanders often required soldiers to take quinine prophylactically.

Adverse Effects and Contraindications

  • Quinine may cause serious and life-threatening bleeding problems.
  • It is contraindicated in patients with a history of hypersensitivity to quinine or any of the excipients in the tablet, in tinnitus or optic neuritis.

Quirky Facts

  • A new gin is celebrating the spirit's historic role in keeping the British Empire healthy by using quinine as an ingredient and supporting a charity.

Further Information

  • Patient medical information for quinine oral can be found on WebMD.
  • Consumer information about Quinine Sulfate (Qualaquin) is available.
  • More product-specific information, including CAS, MSDS, protocols, and references, can be found at Sigma-Aldrich.
  • Detailed annotation of the targets of licensed and experimental drugs is available in The IUPHAR/BPS Guide to Pharmacology.